Intraarticular expression of biologically active interleukin 1-receptor-antagonist protein by ex vivo gene transfer.

Gene therapy offers a radical different approach to the treatment of arthritis. Here we have demonstrated that two marker genes (lacZ and neo) and cDNA coding for a potentially therapeutic protein (human interleukin 1-receptor-antagonist protein; IRAP or IL-1ra) can be delivered, by ex vivo techniqu...

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Detalhes bibliográficos

Publicado no:	Proc Natl Acad Sci U S A
Principais autores:	Bandara, G, Mueller, G M, Galea-Lauri, J, Tindal, M H, Georgescu, H I, Suchanek, M K, Hung, G L, Glorioso, J C, Robbins, P D, Evans, C H
Formato:	Artigo
Idioma:	Inglês
Publicado em:	National Academy of Sciences 1993
Assuntos:	Research Article
Acesso em linha:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47858/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8248169/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.22.10764
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