Intraarticular expression of biologically active interleukin 1-receptor-antagonist protein by ex vivo gene transfer.
Gene therapy offers a radical different approach to the treatment of arthritis. Here we have demonstrated that two marker genes (lacZ and neo) and cDNA coding for a potentially therapeutic protein (human interleukin 1-receptor-antagonist protein; IRAP or IL-1ra) can be delivered, by ex vivo techniqu...
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| Vydáno v: | Proc Natl Acad Sci U S A |
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| Hlavní autoři: | , , , , , , , , , |
| Médium: | Artigo |
| Jazyk: | Inglês |
| Vydáno: |
National Academy of Sciences
1993
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| Témata: | |
| On-line přístup: | https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC47858/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8248169/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.90.22.10764 |
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