Melanoma cell lysosome secretory burst neutralizes the CTL-mediated cytotoxicity at the lytic synapse

Human melanoma cells express various tumour antigens that are recognized by CD8(+) cytotoxic T lymphocytes (CTLs) and elicit tumour-specific responses in vivo. However, natural and therapeutically enhanced CTL responses in melanoma patients are of limited efficacy. The mechanisms underlying CTL effe...

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Vydáno v:Nat Commun
Hlavní autoři: Khazen, Roxana, Müller, Sabina, Gaudenzio, Nicolas, Espinosa, Eric, Puissegur, Marie-Pierre, Valitutti, Salvatore
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4785227/
https://ncbi.nlm.nih.gov/pubmed/26940455
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10823
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