Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Cyclic ADP-Ribose (cADPR) Mediate Ca(2+) Signaling in Cardiac Hypertrophy Induced by β-Adrenergic Stimulation

Ca(2+) signaling plays a fundamental role in cardiac hypertrophic remodeling, but the underlying mechanisms remain poorly understood. We investigated the role of Ca(2+)-mobilizing second messengers, NAADP and cADPR, in the cardiac hypertrophy induced by β-adrenergic stimulation by isoproterenol. Iso...

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Veröffentlicht in:PLoS One
Hauptverfasser: Gul, Rukhsana, Park, Dae-Ryoung, Shawl, Asif Iqbal, Im, Soo-Yeul, Nam, Tae-Sik, Lee, Sun-Hwa, Ko, Jae-Ki, Jang, Kyu Yoon, Kim, Donghee, Kim, Uh-Hyun
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
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Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4784992/
https://ncbi.nlm.nih.gov/pubmed/26959359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0149125
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