Unraveling the Mode of Action of the Antimalarial Choline Analog G25 in Plasmodium falciparum and Saccharomyces cerevisiae

Pharmacological studies have indicated that the choline analog G25 is a potent inhibitor of Plasmodium falciparum growth in vitro and in vivo. Although choline transport has been suggested to be the target of G25, the exact mode of action of this compound is not known. Here we show that, similar to...

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Detalhes bibliográficos
Main Authors: Roggero, Rodolphe, Zufferey, Rachel, Minca, Mihaela, Richier, Eric, Calas, Michele, Vial, Henri, Mamoun, Choukri Ben
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2004
Assuntos:
Mechanisms of Action: Physiological Effects
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC478495/
https://ncbi.nlm.nih.gov/pubmed/15273086
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.8.2816-2824.2004
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