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Role of β-Lactamases and Porins in Resistance to Ertapenem and Other β-Lactams in Klebsiella pneumoniae

High-level resistance to ertapenem was produced by β-lactamases of groups 1, 2f, and 3 in a strain of Klebsiella pneumoniae deficient in Omp35 and Omp36. From a wild-type strain producing ACT-1 β-lactamase, ertapenem-resistant mutants for which the ertapenem MICs were up to 128 μg/ml and expression...

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Autors principals: Jacoby, George A., Mills, Debra M., Chow, Nancy
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2004
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC478483/
https://ncbi.nlm.nih.gov/pubmed/15273152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.48.8.3203-3206.2004
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