Alterations in the mir-15a/16-1 Loci Impairs Its Processing and Augments B-1 Expansion in De Novo Mouse Model of Chronic Lymphocytic Leukemia (CLL)

New Zealand Black (NZB) mice, a de novo model of CLL, share multiple characteristics with CLL patients, including decreased expression of miR-15a/16-1. We previously discovered a point mutation and deletion in the 3' flanking region of mir-16-1 of NZB and a similar mutation has been found in a...

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Détails bibliographiques
Publié dans:PLoS One
Auteurs principaux: Kasar, Siddha, Underbayev, Chingiz, Hassan, Moinuddin, Ilev, Ilko, Degheidy, Heba, Bauer, Steven, Marti, Gerald, Lutz, Carol, Raveche, Elizabeth, Batish, Mona
Format: Artigo
Langue:Inglês
Publié: Public Library of Science 2016
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4784815/
https://ncbi.nlm.nih.gov/pubmed/26959643
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0149331
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