Cross‐reactivity of hepatitis C virus specific vaccine‐induced T cells at immunodominant epitopes

Viral diversity is a challenge to the development of a hepatitis C virus (HCV) vaccine. Following vaccination of humans with adenoviral vectors, we determined the capacity of T cells to target common viral variants at immundominant epitopes ex vivo. We identified two major variants for epitopes NS3(...

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Detalhes bibliográficos
Publicado no:Eur J Immunol
Main Authors: Kelly, Christabel, Swadling, Leo, Brown, Anthony, Capone, Stefania, Folgori, Antonella, Salio, Mariolina, Klenerman, Paul, Barnes, Eleanor
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2014
Assuntos:
Clinical Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4784727/
https://ncbi.nlm.nih.gov/pubmed/25263407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.201444686
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