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Sort-seq under the hood: implications of design choices on large-scale characterization of sequence-function relations

BACKGROUND: Sort-seq is an effective approach for simultaneous activity measurements in a large-scale library, combining flow cytometry, deep sequencing, and statistical inference. Such assays enable the characterization of functional landscapes at unprecedented scale for a wide-reaching array of bi...

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Detalhes bibliográficos
Publicado no:BMC Genomics
Main Authors: Peterman, Neil, Levine, Erel
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4784318/
https://ncbi.nlm.nih.gov/pubmed/26956374
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12864-016-2533-5
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