In silico prediction of drug therapy in catecholaminergic polymorphic ventricular tachycardia

KEY POINTS: The mechanism of therapeutic efficacy of flecainide for catecholaminergic polymorphic ventricular tachycardia (CPVT) is unclear. Model predictions suggest that Na(+) channel effects are insufficient to explain flecainide efficacy in CPVT. This study represents a first step toward predict...

Deskribapen osoa

Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:J Physiol
Egile Nagusiak: Yang, Pei‐Chi, Moreno, Jonathan D., Miyake, Christina Y., Vaughn‐Behrens, Steven B., Jeng, Mao‐Tsuen, Grandi, Eleonora, Wehrens, Xander H. T., Noskov, Sergei Y., Clancy, Colleen E.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: John Wiley and Sons Inc. 2016
Gaiak:
Computational Physiology and Modelling
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4784170/
https://ncbi.nlm.nih.gov/pubmed/26515697
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/JP271282
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