Synthetic Human TLR9-LRR11 Peptide Attenuates TLR9 Signaling by Binding to and thus Decreasing Internalization of CpG Oligodeoxynucleotides

Toll-like receptor (TLR) 9 is an endosomal receptor recognizing bacterial DNA/CpG-containing oligodeoxynucleotides (CpG ODN). Blocking CpG ODN/TLR9 activity represents a strategy for therapeutic prevention of immune system overactivation. Herein, we report that a synthetic peptide (SP) representing...

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Veröffentlicht in:Int J Mol Sci
Hauptverfasser: Pan, Xichun, Li, Bin, Kuang, Mei, Liu, Xin, Cen, Yanyan, Qin, Rongxin, Ding, Guofu, Zheng, Jiang, Zhou, Hong
Format: Artigo
Sprache:Inglês
Veröffentlicht: MDPI 2016
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4783973/
https://ncbi.nlm.nih.gov/pubmed/26907260
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/ijms17020242
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