Generation of the First TCR Transgenic Mouse with CD4(+) T Cells Recognizing an Anti-inflammatory Regulatory T Cell-Inducing Hsp70 Peptide

Antigen-specific regulatory T cells (Tregs) directed at self-antigens are difficult to study since suitable specific tools to isolate and characterize these cells are lacking. A T cell receptor (TCR)-transgenic mouse would generate possibilities to study such ­antigen-specific T cells. As was shown...

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Publicat a:Front Immunol
Autors principals: Jansen, Manon A. A., van Herwijnen, Martijn J. C., van Kooten, Peter J. S., Hoek, Aad, van der Zee, Ruurd, van Eden, Willem, Broere, Femke
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2016
Matèries:
Immunology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4783572/
https://ncbi.nlm.nih.gov/pubmed/27014269
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2016.00090
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