Development of a Self-Assembled Nanoparticle Formulation of Orlistat, Nano-ORL, with Increased Cytotoxicity against Human Tumor Cell Lines

Fatty acid synthase (FASN), the enzyme that catalyzes de novo synthesis of fatty acids, is expressed in many cancer types. Its potential as a therapeutic target is well recognized, but inhibitors of FASN have not yet been approved for cancer therapy. Orlistat (ORL), an FDA-approved lipase inhibitor,...

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Udgivet i:Mol Pharm
Main Authors: Hill, Tanner K., Davis, Amanda L., Wheeler, Frances B., Kelkar, Sneha S., Freund, Erica C., Lowther, W. Todd, Kridel, Steven J., Mohs, Aaron M.
Format: Artigo
Sprog:Inglês
Udgivet: 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4783219/
https://ncbi.nlm.nih.gov/pubmed/26824142
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.molpharmaceut.5b00447
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