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Combination treatment with orlistat-containing nanoparticles and taxanes is synergistic and enhances microtubule stability in taxane-resistant prostate cancer cells

Taxane-based therapy provides a survival benefit in patients with metastatic prostate cancer, yet the median survival is less than 20 months in this setting due in part to taxane-associated resistance. Innovative strategies are required to overcome chemoresistance for improved patient survival. Here...

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Detalhes bibliográficos
Publicado no:Mol Cancer Ther
Main Authors: Souchek, Joshua J., Davis, Amanda L., Hill, Tanner K., Holmes, Megan B., Qi, Bowen, Singh, Pankaj K., Kridel, Steven J., Mohs, Aaron M.
Formato: Artigo
Idioma:Inglês
Publicado em: 2017
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5598554/
https://ncbi.nlm.nih.gov/pubmed/28615298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1535-7163.MCT-17-0013
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