SMN Protein Can Be Reliably Measured in Whole Blood with an Electrochemiluminescence (ECL) Immunoassay: Implications for Clinical Trials

Spinal muscular atrophy (SMA) is caused by defects in the survival motor neuron 1 (SMN1) gene that encodes survival motor neuron (SMN) protein. The majority of therapeutic approaches currently in clinical development for SMA aim to increase SMN protein expression and there is a need for sensitive me...

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Pubblicato in:PLoS One
Autori principali: Zaworski, Phillip, von Herrmann, Katharine M., Taylor, Shannon, Sunshine, Sara S., McCarthy, Kathleen, Risher, Nicole, Newcomb, Tara, Weetall, Marla, Prior, Thomas W., Swoboda, Kathryn J., Chen, Karen S., Paushkin, Sergey
Natura: Artigo
Lingua:Inglês
Pubblicazione: Public Library of Science 2016
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4783032/
https://ncbi.nlm.nih.gov/pubmed/26953792
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0150640
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