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Pancreatic B-13 Cell Trans-Differentiation to Hepatocytes Is Dependent on Epigenetic-Regulated Changes in Gene Expression

The proliferative B-13 pancreatic cell line is unique in its ability to generate functional hepatocyte-like (B-13/H) cells in response to exposure to glucocorticoid. In these studies, quantitatively comparable hepatic levels of liver-specific and liver-enriched transcription factor and hepatocyte de...

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Veröffentlicht in:PLoS One
Hauptverfasser: Fairhall, Emma A., Charles, Michelle A., Probert, Philip M. E., Wallace, Karen, Gibb, Jennifer, Ravindan, Chandni, Soloman, Martin, Wright, Matthew C.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Public Library of Science 2016
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4782989/
https://ncbi.nlm.nih.gov/pubmed/26954030
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0150959
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