IGF-1R inhibition in mammary epithelia promotes canonical Wnt signaling and Wnt1-driven tumors

Triple-negative breast cancers (TNBC) are an aggressive disease subtype which unlike other subtypes lack an effective targeted therapy. Inhibitors of the insullin-like growth factor receptor (IGF-1R) have been considered for use in treating TNBC. Here we provide genetic evidence that IGF-1R inhibiti...

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Detalhes bibliográficos
Publicado no:Cancer Res
Main Authors: Rota, Lauren M., Albanito, Lidia, Shin, Marcus E., Goyeneche, Corey L., Shushanov, Sain, Gallagher, Emily J., LeRoith, Derek, Lazzarino, Deborah A., Wood, Teresa L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4782979/
https://ncbi.nlm.nih.gov/pubmed/25092896
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-14-0970
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