Targeting Rad50 sensitizes human nasopharyngeal carcinoma cells to radiotherapy

BACKGROUND: The Mre11-Rad50-Nbs1 (MRN) complex is well known for its crucial role in initiating DNA double strand breaks (DSBs) repair pathways to resistant irradiation (IR) injury and thus facilitating radioresistance which severely reduces radiocurability of nasopharyngeal cancer (NPC). Targeting...

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Detaylı Bibliyografya
Yayımlandı:BMC Cancer
Asıl Yazarlar: Chang, Lihong, Huang, Jiancong, Wang, Kai, Li, Jingjia, Yan, Ruicheng, Zhu, Ling, Ye, Jin, Wu, Xifu, Zhuang, Shimin, Li, Daqing, Zhang, Gehua
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: BioMed Central 2016
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4782334/
https://ncbi.nlm.nih.gov/pubmed/26951044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2190-8
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