Targeting Rad50 sensitizes human nasopharyngeal carcinoma cells to radiotherapy

BACKGROUND: The Mre11-Rad50-Nbs1 (MRN) complex is well known for its crucial role in initiating DNA double strand breaks (DSBs) repair pathways to resistant irradiation (IR) injury and thus facilitating radioresistance which severely reduces radiocurability of nasopharyngeal cancer (NPC). Targeting...

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Detalhes bibliográficos
Publicado no:BMC Cancer
Main Authors: Chang, Lihong, Huang, Jiancong, Wang, Kai, Li, Jingjia, Yan, Ruicheng, Zhu, Ling, Ye, Jin, Wu, Xifu, Zhuang, Shimin, Li, Daqing, Zhang, Gehua
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2016
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4782334/
https://ncbi.nlm.nih.gov/pubmed/26951044
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12885-016-2190-8
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