B-Cell-Deficient and CD8 T-Cell-Depleted Gnotobiotic Pigs for the Study of Human Rotavirus Vaccine-Induced Protective Immune Responses

Genetically modified pigs have become available recently. In this study, we established the gnotobiotic pig model of human rotavirus (HRV) infection using cloned pigs with homozygous disruption in the gene encoding immunoglobulin heavy chain (HCKO), which totally impairs B-cell development. To clari...

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Библиографические подробности
Опубликовано в: :Viral Immunol
Главные авторы: Wen, Ke, Bui, Tammy, Weiss, Mariah, Li, Guohua, Kocher, Jacob, Yang, Xingdong, Jobst, Peter M., Vaught, Todd, Ramsoondar, Jagdeece, Ball, Suyapa, Clark-Deener, Sherrie, Ayares, David, Yuan, Lijuan
Формат: Artigo
Язык:Inglês
Опубликовано: Mary Ann Liebert, Inc. 2016
Предметы:
Original Research Articles
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4782039/
https://ncbi.nlm.nih.gov/pubmed/26824402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/vim.2015.0105
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