B-Cell-Deficient and CD8 T-Cell-Depleted Gnotobiotic Pigs for the Study of Human Rotavirus Vaccine-Induced Protective Immune Responses

Genetically modified pigs have become available recently. In this study, we established the gnotobiotic pig model of human rotavirus (HRV) infection using cloned pigs with homozygous disruption in the gene encoding immunoglobulin heavy chain (HCKO), which totally impairs B-cell development. To clari...

Täydet tiedot

Tallennettuna:
Bibliografiset tiedot
Julkaisussa:Viral Immunol
Päätekijät: Wen, Ke, Bui, Tammy, Weiss, Mariah, Li, Guohua, Kocher, Jacob, Yang, Xingdong, Jobst, Peter M., Vaught, Todd, Ramsoondar, Jagdeece, Ball, Suyapa, Clark-Deener, Sherrie, Ayares, David, Yuan, Lijuan
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Mary Ann Liebert, Inc. 2016
Aiheet:
Original Research Articles
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC4782039/
https://ncbi.nlm.nih.gov/pubmed/26824402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/vim.2015.0105
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