B-Cell-Deficient and CD8 T-Cell-Depleted Gnotobiotic Pigs for the Study of Human Rotavirus Vaccine-Induced Protective Immune Responses

Genetically modified pigs have become available recently. In this study, we established the gnotobiotic pig model of human rotavirus (HRV) infection using cloned pigs with homozygous disruption in the gene encoding immunoglobulin heavy chain (HCKO), which totally impairs B-cell development. To clari...

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Detalhes bibliográficos
Publicado no:Viral Immunol
Main Authors: Wen, Ke, Bui, Tammy, Weiss, Mariah, Li, Guohua, Kocher, Jacob, Yang, Xingdong, Jobst, Peter M., Vaught, Todd, Ramsoondar, Jagdeece, Ball, Suyapa, Clark-Deener, Sherrie, Ayares, David, Yuan, Lijuan
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2016
Assuntos:
Original Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4782039/
https://ncbi.nlm.nih.gov/pubmed/26824402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/vim.2015.0105
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