B-Cell-Deficient and CD8 T-Cell-Depleted Gnotobiotic Pigs for the Study of Human Rotavirus Vaccine-Induced Protective Immune Responses

Genetically modified pigs have become available recently. In this study, we established the gnotobiotic pig model of human rotavirus (HRV) infection using cloned pigs with homozygous disruption in the gene encoding immunoglobulin heavy chain (HCKO), which totally impairs B-cell development. To clari...

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Bibliographische Detailangaben
Veröffentlicht in:Viral Immunol
Hauptverfasser: Wen, Ke, Bui, Tammy, Weiss, Mariah, Li, Guohua, Kocher, Jacob, Yang, Xingdong, Jobst, Peter M., Vaught, Todd, Ramsoondar, Jagdeece, Ball, Suyapa, Clark-Deener, Sherrie, Ayares, David, Yuan, Lijuan
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mary Ann Liebert, Inc. 2016
Schlagworte:
Original Research Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4782039/
https://ncbi.nlm.nih.gov/pubmed/26824402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/vim.2015.0105
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