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The BH3 Mimetic Obatoclax Accumulates in Lysosomes and Causes Their Alkalinization
Obatoclax belongs to a class of compounds known as BH3 mimetics which function as antagonists of Bcl-2 family apoptosis regulators. It has undergone extensive preclinical and clinical evaluation as a cancer therapeutic. Despite this, it is clear that obatoclax has additional pharmacological effects...
Shranjeno v:
| izdano v: | PLoS One |
|---|---|
| Main Authors: | , , , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
Public Library of Science
2016
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4780728/ https://ncbi.nlm.nih.gov/pubmed/26950068 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0150696 |
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