The BH3 Mimetic Obatoclax Accumulates in Lysosomes and Causes Their Alkalinization

Obatoclax belongs to a class of compounds known as BH3 mimetics which function as antagonists of Bcl-2 family apoptosis regulators. It has undergone extensive preclinical and clinical evaluation as a cancer therapeutic. Despite this, it is clear that obatoclax has additional pharmacological effects...

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Bibliographic Details
Published in:PLoS One
Main Authors: Stamelos, Vasileios A., Fisher, Natalie, Bamrah, Harnoor, Voisey, Carolyn, Price, Joshua C., Farrell, William E., Redman, Charles W., Richardson, Alan
Format: Artigo
Language:Inglês
Published: Public Library of Science 2016
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4780728/
https://ncbi.nlm.nih.gov/pubmed/26950068
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0150696
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