Cholesteryl esters stabilize human CD1c conformations for recognition by self-reactive T cells

Cluster of differentiation 1c (CD1c)-dependent self-reactive T cells are abundant in human blood, but self-antigens presented by CD1c to the T-cell receptors of these cells are poorly understood. Here we present a crystal structure of CD1c determined at 2.4 Å revealing an extended ligand binding pot...

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Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Mansour, Salah, Tocheva, Anna S., Cave-Ayland, Chris, Machelett, Moritz M., Sander, Barbara, Lissin, Nikolai M., Molloy, Peter E., Baird, Mark S., Stübs, Gunthard, Schröder, Nicolas W. J., Schumann, Ralf R., Rademann, Jörg, Postle, Anthony D., Jakobsen, Bent K., Marshall, Ben G., Gosain, Rajendra, Elkington, Paul T., Elliott, Tim, Skylaris, Chris-Kriton, Essex, Jonathan W., Tews, Ivo, Gadola, Stephan D.
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2016
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PNAS Plus
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4780616/
https://ncbi.nlm.nih.gov/pubmed/26884207
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1519246113
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