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Single-molecule imaging reveals the mechanism of Exo1 regulation by single-stranded DNA binding proteins
Exonuclease 1 (Exo1) is a 5′→3′ exonuclease and 5′-flap endonuclease that plays a critical role in multiple eukaryotic DNA repair pathways. Exo1 processing at DNA nicks and double-strand breaks creates long stretches of single-stranded DNA, which are rapidly bound by replication protein A (RPA) and...
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| Publicado no: | Proc Natl Acad Sci U S A |
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| Main Authors: | , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4780606/ https://ncbi.nlm.nih.gov/pubmed/26884156 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1516674113 |
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