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Acute and gradual increases in BDNF concentration elicit distinct signaling and functions in hippocampal neurons

Extracellular factors may act on cells in two distinct modes: an acute increase in concentration due to regulated secretion, or a gradual increase in concentration when secreted constitutively or from a distant source. We show that cellular responses to BDNF differ dramatically depending on how BDNF...

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Vydáno v:Nat Neurosci
Hlavní autoři: Ji, Yuanyuan, Lu, Yuan, Yang, Feng, Shen, Wanhua, Tang, Tina Tze-Tsang, Feng, Linyin, Duan, Shumin, Lu, Bai
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4780419/
https://ncbi.nlm.nih.gov/pubmed/20173744
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2505
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