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Mutant Kras copy number defines metabolic reprogramming and therapeutic susceptibilities
The RAS/MAPK-signalling pathway is frequently deregulated in non-small cell lung cancer (NSCLC), often through KRAS activating mutations(1-3). A single endogenous mutant Kras allele is sufficient to promote lung tumour formation in mice but malignant progression requires additional genetic alteratio...
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| Publicado no: | Nature |
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| Main Authors: | , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2016
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4780242/ https://ncbi.nlm.nih.gov/pubmed/26909577 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nature16967 |
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