Naringenin-loaded solid lipid nanoparticles: preparation, controlled delivery, cellular uptake, and pulmonary pharmacokinetics

Naringenin (NRG), a flavonoid compound, had been reported to exhibit extensive pharmacological effects, but its water solubility and oral bioavailability are only~46±6 µg/mL and 5.8%, respectively. The purpose of this study is to design and develop NRG-loaded solid lipid nanoparticles (NRG-SLNs) to...

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Bibliographische Detailangaben
Veröffentlicht in:Drug Des Devel Ther
Hauptverfasser: Ji, Peng, Yu, Tong, Liu, Ying, Jiang, Jie, Xu, Jie, Zhao, Ying, Hao, Yanna, Qiu, Yang, Zhao, Wenming, Wu, Chao
Format: Artigo
Sprache:Inglês
Veröffentlicht: Dove Medical Press 2016
Schlagworte:
Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4780207/
https://ncbi.nlm.nih.gov/pubmed/27041995
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S97738
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