Increasing TRPV4 expression restores flow-induced dilation impaired in mesenteric arteries with aging

The flow-stimulated intracellular Ca(2+) concentration ([Ca(2+)](i)) rise in endothelial cells is an important early event leading to flow-induced blood vessel dilation. Transient receptor potential vanilloid subtype 4 (TRPV4), a Ca(2+)-permeable cation channel, facilitates the flow-stimulated [Ca(2...

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Vydáno v:Sci Rep
Hlavní autoři: Du, Juan, Wang, Xia, Li, Jie, Guo, Jizheng, Liu, Limei, Yan, Dejun, Yang, Yunyun, Li, Zhongwen, Zhu, Jinhang, Shen, Bing
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4780030/
https://ncbi.nlm.nih.gov/pubmed/26947561
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22780
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