Neutralizing Monoclonal Antibodies against Disparate Epitopes on Ricin Toxin’s Enzymatic Subunit Interfere with Intracellular Toxin Transport

Ricin is a member of the A-B family of bacterial and plant toxins that exploit retrograde trafficking to the Golgi apparatus and endoplasmic reticulum (ER) as a means to deliver their cytotoxic enzymatic subunits into the cytoplasm of mammalian cells. In this study we demonstrate that R70 and SyH7,...

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Bibliographic Details
Published in:Sci Rep
Main Authors: Yermakova, Anastasiya, Klokk, Tove Irene, O’Hara, Joanne M., Cole, Richard, Sandvig, Kirsten, Mantis, Nicholas J.
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2016
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4779987/
https://ncbi.nlm.nih.gov/pubmed/26949061
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22721
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