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Germline genetic variants in the Wnt/beta-catenin pathway as predictors of colorectal cancer risk

BACKGROUND: The Wnt/beta-catenin signaling pathway plays a key role in stem cell maintenance in the colorectum. Rare high penetrance genetic mutations in components of this pathway result in familial colorectal cancer, yet the impact of common, germline variants remains unknown. METHODS: We assessed...

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Publicat a:Cancer Epidemiol Biomarkers Prev
Autors principals: Hildebrandt, Michelle A.T., Reyes, Monica E., Lin, Moubin, He, Yonggang, Nguyen, Son V., Hawk, Ernest T., Wu, Xifeng
Format: Artigo
Idioma:Inglês
Publicat: 2016
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4779688/
https://ncbi.nlm.nih.gov/pubmed/26809274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1055-9965.EPI-15-0834
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