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Germline genetic variants in the Wnt/beta-catenin pathway as predictors of colorectal cancer risk

BACKGROUND: The Wnt/beta-catenin signaling pathway plays a key role in stem cell maintenance in the colorectum. Rare high penetrance genetic mutations in components of this pathway result in familial colorectal cancer, yet the impact of common, germline variants remains unknown. METHODS: We assessed...

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Detalhes bibliográficos
Publicado no:Cancer Epidemiol Biomarkers Prev
Main Authors: Hildebrandt, Michelle A.T., Reyes, Monica E., Lin, Moubin, He, Yonggang, Nguyen, Son V., Hawk, Ernest T., Wu, Xifeng
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4779688/
https://ncbi.nlm.nih.gov/pubmed/26809274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1055-9965.EPI-15-0834
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