Germline genetic variants in the Wnt/beta-catenin pathway as predictors of colorectal cancer risk

BACKGROUND: The Wnt/beta-catenin signaling pathway plays a key role in stem cell maintenance in the colorectum. Rare high penetrance genetic mutations in components of this pathway result in familial colorectal cancer, yet the impact of common, germline variants remains unknown. METHODS: We assessed...

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Xehetasun bibliografikoak
Argitaratua izan da:Cancer Epidemiol Biomarkers Prev
Egile Nagusiak: Hildebrandt, Michelle A.T., Reyes, Monica E., Lin, Moubin, He, Yonggang, Nguyen, Son V., Hawk, Ernest T., Wu, Xifeng
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 2016
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4779688/
https://ncbi.nlm.nih.gov/pubmed/26809274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1055-9965.EPI-15-0834
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