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Germline genetic variants in the Wnt/beta-catenin pathway as predictors of colorectal cancer risk

BACKGROUND: The Wnt/beta-catenin signaling pathway plays a key role in stem cell maintenance in the colorectum. Rare high penetrance genetic mutations in components of this pathway result in familial colorectal cancer, yet the impact of common, germline variants remains unknown. METHODS: We assessed...

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Bibliografski detalji
Izdano u:Cancer Epidemiol Biomarkers Prev
Glavni autori: Hildebrandt, Michelle A.T., Reyes, Monica E., Lin, Moubin, He, Yonggang, Nguyen, Son V., Hawk, Ernest T., Wu, Xifeng
Format: Artigo
Jezik:Inglês
Izdano: 2016
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4779688/
https://ncbi.nlm.nih.gov/pubmed/26809274
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1055-9965.EPI-15-0834
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