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Feedback Regulation of G Protein-Coupled Receptor Signaling by GRKs and Arrestins
GPCR are ubiquitous in mammalian cells and present intricate mechanisms for cellular signaling and communication. Mechanistically, GPCR signaling was identified to occur vectorially through heterotrimeric G proteins that are negatively regulated by GRK and arrestin effectors. Emerging evidence highl...
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| Published in: | Semin Cell Dev Biol |
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| Main Authors: | , , |
| Format: | Artigo |
| Language: | Inglês |
| Published: |
2016
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4779377/ https://ncbi.nlm.nih.gov/pubmed/26773211 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.semcdb.2015.12.015 |
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