Bmi1 Is a Key Epigenetic Barrier to Direct Cardiac Reprogramming

Direct reprogramming of induced cardiomyocytes (iCMs) suffers from low efficiency and requires extensive epigenetic repatterning, although the underlying mechanisms are largely unknown. To address these issues, we screened for epigenetic regulators of iCM reprogramming and found that reducing levels...

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Publicado en:Cell Stem Cell
Autores principales: Zhou, Yang, Wang, Li, Vaseghi, Haley Ruth, Liu, Ziqing, Lu, Rui, Alimohamadi, Sahar, Yin, Chaoying, Fu, Ji-Dong, Wang, Greg G., Liu, Jiandong, Qian, Li
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4779178/
https://ncbi.nlm.nih.gov/pubmed/26942853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2016.02.003
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