Bmi1 Is a Key Epigenetic Barrier to Direct Cardiac Reprogramming

Direct reprogramming of induced cardiomyocytes (iCMs) suffers from low efficiency and requires extensive epigenetic repatterning, although the underlying mechanisms are largely unknown. To address these issues, we screened for epigenetic regulators of iCM reprogramming and found that reducing levels...

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Detalhes bibliográficos
Publicado no:Cell Stem Cell
Main Authors: Zhou, Yang, Wang, Li, Vaseghi, Haley Ruth, Liu, Ziqing, Lu, Rui, Alimohamadi, Sahar, Yin, Chaoying, Fu, Ji-Dong, Wang, Greg G., Liu, Jiandong, Qian, Li
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4779178/
https://ncbi.nlm.nih.gov/pubmed/26942853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.stem.2016.02.003
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