Prophylactic vaccines are potent activators of monocyte-derived dendritic cells and drive effective anti-tumor responses in melanoma patients at the cost of toxicity

Dendritic cell (DC)-based immunotherapy is explored worldwide in cancer patients, predominantly with DC matured with pro-inflammatory cytokines and prostaglandin E(2). We studied the safety and efficacy of vaccination with monocyte-derived DC matured with a cocktail of prophylactic vaccines that con...

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Veröffentlicht in:Cancer Immunol Immunother
Hauptverfasser: Bol, Kalijn F., Aarntzen, Erik H. J. G., Pots, Jeanette M., Olde Nordkamp, Michel A. M., van de Rakt, Mandy W. M. M., Scharenborg, Nicole M., de Boer, Annemiek J., van Oorschot, Tom G. M., Croockewit, Sandra A. J., Blokx, Willeke A. M., Oyen, Wim J. G., Boerman, Otto C., Mus, Roel D. M., van Rossum, Michelle M., van der Graaf, Chantal A. A., Punt, Cornelis J. A., Adema, Gosse J., Figdor, Carl G., de Vries, I. Jolanda M., Schreibelt, Gerty
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Berlin Heidelberg 2016
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4779136/
https://ncbi.nlm.nih.gov/pubmed/26861670
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s00262-016-1796-7
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