Vitamin C selectively kills KRAS and BRAF mutant colorectal cancer cells by targeting GAPDH

More than half of human colorectal cancers (CRCs) carry either KRAS or BRAF mutations, and are often refractory to approved targeted therapies. We report that cultured CRC cells harboring KRAS or BRAF mutations are selectively killed when exposed to high levels of vitamin C. This effect is due to in...

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Detalhes bibliográficos
Publicado no:Science
Main Authors: Yun, Jihye, Mullarky, Edouard, Lu, Changyuan, Bosch, Kaitlyn N., Kavalier, Adam, Rivera, Keith, Roper, Jatin, Chio, Iok In Christine, Giannopoulou, Eugenia G., Rago, Carlo, Muley, Ashlesha, Asara, John M., Paik, Jihye, Elemento, Olivier, Chen, Zhengming, Pappin, Darryl J., Dow, Lukas E., Papadopoulos, Nickolas, Gross, Steven S., Cantley, Lewis C.
Formato: Artigo
Idioma:Inglês
Publicado em: 2015
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4778961/
https://ncbi.nlm.nih.gov/pubmed/26541605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/science.aaa5004
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