Organocatalytic asymmetric Henry reaction of 1H-pyrrole-2,3-diones with bifunctional amine-thiourea catalysts bearing multiple hydrogen-bond donors

For the first time, a catalytic asymmetric Henry reaction of 1H-pyrrole-2,3-diones was achieved with a chiral bifunctional amine-thiourea as a catalyst possessing multiple hydrogen-bond donors. With this developed method, a range of 3-hydroxy-3-nitromethyl-1H-pyrrol-2(3H)-ones bearing quaternary ste...

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Veröffentlicht in:Beilstein J Org Chem
Hauptverfasser: Zhang, Ming-Liang, Yue, Deng-Feng, Wang, Zhen-Hua, Luo, Yuan, Xu, Xiao-Ying, Zhang, Xiao-Mei, Yuan, Wei-Cheng
Format: Artigo
Sprache:Inglês
Veröffentlicht: Beilstein-Institut 2016
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Full Research Paper
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4778496/
https://ncbi.nlm.nih.gov/pubmed/26977188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3762/bjoc.12.31
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