GSG1L suppresses AMPA receptor-mediated synaptic transmission and uniquely modulates AMPA receptor kinetics in hippocampal neurons

Regulation of AMPA receptor (AMPAR)-mediated synaptic transmission is a key mechanism for synaptic plasticity. In the brain, AMPARs assemble with a number of auxiliary subunits, including TARPs, CNIHs and CKAMP44, which are important for AMPAR forward trafficking to synapses. Here we report that the...

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Udgivet i:Nat Commun
Main Authors: Gu, Xinglong, Mao, Xia, Lussier, Marc P., Hutchison, Mary Anne, Zhou, Liang, Hamra, F. Kent, Roche, Katherine W., Lu, Wei
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group 2016
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4778064/
https://ncbi.nlm.nih.gov/pubmed/26932439
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms10873
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