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Class III-specific HDAC inhibitor Tenovin-6 induces apoptosis, suppresses migration and eliminates cancer stem cells in uveal melanoma

Uveal melanoma (UM) is the most common intraocular malignancy in adults. Despite improvements in surgical, radiation and chemotherapy treatments, the overall survival of UM and prognosis remain poor. In the present study, we hypothesized that Sirtuin 1 and 2 (SIRT1/2), class III histone deacetylases...

詳細記述

保存先:
書誌詳細
出版年:Sci Rep
主要な著者: Dai, Wei, Zhou, Jingfeng, Jin, Bei, Pan, Jingxuan
フォーマット: Artigo
言語:Inglês
出版事項: Nature Publishing Group 2016
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC4778058/
https://ncbi.nlm.nih.gov/pubmed/26940009
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22622
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