Suppression of the invasive potential of Glioblastoma cells by mTOR inhibitors involves modulation of NFκB and PKC-α signaling

Glioblastoma (GBM) is the most aggressive type of brain tumors in adults with survival period <1.5 years of patients. The role of mTOR pathway is documented in invasion and migration, the features associated with aggressive phenotype in human GBM. However, most of the preclinical and clinical stu...

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Vydáno v:Sci Rep
Hlavní autoři: Chandrika, Goparaju, Natesh, Kumar, Ranade, Deepak, Chugh, Ashish, Shastry, Padma
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2016
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC4778030/
https://ncbi.nlm.nih.gov/pubmed/26940200
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22455
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