Intratumoral heterogeneity identified at the epigenetic, genetic and transcriptional level in glioblastoma

Heterogeneity is a hallmark of glioblastoma with intratumoral heterogeneity contributing to variability in responses and resistance to standard treatments. Promoter methylation status of the DNA repair enzyme O(6)-methylguanine DNA methyltransferase (MGMT) is the most important clinical biomarker in...

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Enregistré dans:
Détails bibliographiques
Publié dans:Sci Rep
Auteurs principaux: Parker, Nicole R., Hudson, Amanda L., Khong, Peter, Parkinson, Jonathon F., Dwight, Trisha, Ikin, Rowan J., Zhu, Ying, Cheng, Zhangkai Jason, Vafaee, Fatemeh, Chen, Jason, Wheeler, Helen R., Howell, Viive M.
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2016
Sujets:
Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4778014/
https://ncbi.nlm.nih.gov/pubmed/26940435
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/srep22477
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