VAMP-associated Proteins (VAP) as Receptors That Couple Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) Proteostasis with Lipid Homeostasis

Unesterified cholesterol accumulates in late endosomes in cells expressing the misfolded cystic fibrosis transmembrane conductance regulator (CFTR). CFTR misfolding in the endoplasmic reticulum (ER) or general activation of ER stress led to dynein-mediated clustering of cholesterol-loaded late endos...

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Détails bibliographiques
Publié dans:J Biol Chem
Auteurs principaux: Ernst, Wayne L., Shome, Kuntala, Wu, Christine C., Gong, Xiaoyan, Frizzell, Raymond A., Aridor, Meir
Format: Artigo
Langue:Inglês
Publié: American Society for Biochemistry and Molecular Biology 2016
Sujets:
Protein Synthesis and Degradation
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4777854/
https://ncbi.nlm.nih.gov/pubmed/26740627
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.692749
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