Crystal Structure of the CTP1L Endolysin Reveals How Its Activity Is Regulated by a Secondary Translation Product

Bacteriophages produce endolysins, which lyse the bacterial host cell to release newly produced virions. The timing of lysis is regulated and is thought to involve the activation of a molecular switch. We present a crystal structure of the activated endolysin CTP1L that targets Clostridium tyrobutyr...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: Dunne, Matthew, Leicht, Stefan, Krichel, Boris, Mertens, Haydyn D. T., Thompson, Andrew, Krijgsveld, Jeroen, Svergun, Dmitri I., Gómez-Torres, Natalia, Garde, Sonia, Uetrecht, Charlotte, Narbad, Arjan, Mayer, Melinda J., Meijers, Rob
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2016
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4777826/
https://ncbi.nlm.nih.gov/pubmed/26683375
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M115.671172
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