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THE DMP1-SOST TRANSGENE INTERACTS WITH AND DOWNREGULATES THE DMP1-CRE TRANSGENE AND THE ROSA(NOTCH) ALLELE
Activation of Notch1 in osteocytes of Rosa(Notch) mice, where a loxP-flanked STOP cassette and the Nicd coding sequence were targeted to the reverse orientation splice acceptor (Rosa)26 locus, causes osteopetrosis associated with suppressed Sost expression and enhanced Wnt signaling. To determine wh...
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| Veröffentlicht in: | J Cell Biochem |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
2015
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4777692/ https://ncbi.nlm.nih.gov/pubmed/26456319 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.25405 |
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