Healthy and diseased corticospinal motor neurons are selectively transduced upon direct AAV2-2 injection into the motor cortex

Direct gene delivery to the neurons of interest, without affecting other neuron populations in the cerebral cortex, represent a challenge owing to the heterogeneity and cellular complexity of the brain. Genetic modulation of corticospinal motor neurons (CSMN) is required for developing effective and...

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Detalhes bibliográficos
Publicado no:Gene Ther
Main Authors: Jara, J H, Stanford, M J, Zhu, Y, Tu, M, Hauswirth, W W, Bohn, M C, DeVries, S H, Özdinler, P H
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2016
Assuntos:
Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4777664/
https://ncbi.nlm.nih.gov/pubmed/26704722
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/gt.2015.112
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