CXCL9 Regulates TGF-β1 induced Epithelial to Mesenchymal Transition in Human Alveolar Epithelial Cells

Epithelial to mesenchymal transition (EMT), whereby fully differentiated epithelial cells transition to a mesenchymal phenotype has been implicated in the pathogenesis of idiopathic pulmonary fibrosis (IPF). CXCR3 and its ligands are recognized to play a protective role in pulmonary fibrosis. In thi...

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Veröffentlicht in:J Immunol
Hauptverfasser: O’Beirne, Sarah L, Walsh, Sinead M, Fabre, Aurélie, Reviriego, Carlota, Worrell, Julie C, Counihan, Ian P, Lumsden, Robert V, Cramton-Barnes, Jennifer, Belperio, John A., Donnelly, Seamas C, Boylan, Denise, Marchal-Somme, Joëlle, Kane, Rosemary, Keane, Michael P
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2015
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4777321/
https://ncbi.nlm.nih.gov/pubmed/26268659
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4049/jimmunol.1402008
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