Papaverine inhibits lipopolysaccharide-induced microglial activation by suppressing NF-κB signaling pathway

OBJECTIVE: To investigate the effects of papaverine (PAP) on lipopolysaccharide (LPS)-induced microglial activation and its possible mechanisms. MATERIALS AND METHODS: BV2 microglial cells were first pretreated with PAP (0, 0.4, 2, 10, and 50 μg/mL) and then received LPS stimulation. Transcription a...

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Detalhes bibliográficos
Publicado no:Drug Des Devel Ther
Main Authors: Dang, Yalong, Mu, Yalin, Wang, Kun, Xu, Ke, Yang, Jing, Zhu, Yu, Luo, Bin
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2016
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4777259/
https://ncbi.nlm.nih.gov/pubmed/27013863
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/DDDT.S97380
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