Induction of mitochondrial reactive oxygen species production by GSH mediated S-glutathionylation of 2-oxoglutarate dehydrogenase

2-Oxoglutarate dehydrogenase (Ogdh) is an important mitochondria redox sensor that can undergo S-glutathionylation following an increase in H(2)O(2) levels. Although S-glutathionylation is required to protect Ogdh from irreversible oxidation while simultaneously modulating its activity it remains un...

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Udgivet i:Redox Biol
Main Authors: Mailloux, Ryan J., Craig Ayre, D., Christian, Sherri L.
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2016
Fag:
Research Paper
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4776629/
https://ncbi.nlm.nih.gov/pubmed/26928132
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.redox.2016.02.002
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