Inactivation of Pyruvate Dehydrogenase Kinase 2 by Mitochondrial Reactive Oxygen Species

Reactive oxygen species are byproducts of mitochondrial respiration and thus potential regulators of mitochondrial function. Pyruvate dehydrogenase kinase 2 (PDHK2) inhibits the pyruvate dehydrogenase complex, thereby regulating entry of carbohydrates into the tricarboxylic acid (TCA) cycle. Here we...

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Detalhes bibliográficos
Main Authors: Hurd, Thomas R., Collins, Yvonne, Abakumova, Irina, Chouchani, Edward T., Baranowski, Bartlomiej, Fearnley, Ian M., Prime, Tracy A., Murphy, Michael P., James, Andrew M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2012
Assuntos:
Bioenergetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3471752/
https://ncbi.nlm.nih.gov/pubmed/22910903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M112.400002
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