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Topological constraints and modular structure in the folding and functional motions of GlpG, an intramembrane protease

We investigate the folding of GlpG, an intramembrane protease, using perfectly funneled structure-based models that implicitly account for the absence or presence of the membrane. These two models are used to describe, respectively, folding in detergent micelles and folding within a bilayer, which e...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Autores principales: Schafer, Nicholas P., Truong, Ha H., Otzen, Daniel E., Lindorff-Larsen, Kresten, Wolynes, Peter G.
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2016
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4776503/
https://ncbi.nlm.nih.gov/pubmed/26858402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1524027113
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